王梓源，博士，永利集团3044浏览器讲师，硕士生导师。
教育经历
2013.09-2019.06，天津大学，生物化工，硕博连读
2009.09-2013.06，天津大学，生物工程，本科
主讲课程
本科生：酶工程；生物分离工程
留学生：Enzyme engineering；Fermentation engineering；Environmental biotechnology
科研领域及方向
[1] 智能包装材料：腐败实时监测标签、长效抗菌保鲜膜
[2] 功能性递送系统：酶/活性成分靶向控释技术
科研项目情况
[1] 中国博士后科学基金，面上项目，仿生金属有机框架构建的多功能荧光探针实现血清Aβ40与Aβ42的联合高效检测，2024M760338，2024.08-2026.01，主持
[2] 天津市科学技术局，面上项目，层层自组装的智能pH响应型苯丙氨酸解氨酶递送系统及其应用研究，21JCYBJC01390，2021.10-2024.09，主持
[3] 广西壮族自治区科学技术厅，重点研发项目，天然抑菌剂绿原酸微生物合成关键技术及无抗健康养殖应用示范，Guike AB 21238005，2022.01-2024.12，参与
[4] 国家自然科学基金委员会，面上项目，活性氧通过氧化翻译后修饰调控发菜多糖合成的作用机制研究，32172191，2022.01-2025.12，参与
[5] 天津市科学技术局，科技计划项目，天然食品添加剂及功能食品活性成分的生物制造研发平台的构建及研究，20ZYJDJC00080，2020.04-2022.03，参与
[6] 国家自然科学基金委员会，重大研究计划，纳米马达对蛋白质聚集和解聚反应过程的调控与强化，91634119，2017.01-2019.12，参与
[7] 国家自然科学基金委员会，面上项目，细胞膜表面小分子抑制淀粉样β多肽构象转换和聚集的多尺度研究，21576199，2016.01-2019.12，参与
主要学术成果
先后发表各类科研论文十余篇，申请发明专利2项。发表的主要学术论文有：
[1] Le Zhong, Zhongjie Wang, Xiaohong Ye, Jiandong Cui*, Ziyuan Wang*, Shiru Jia. Molecular simulations guide immobilization of lipase on nest-like ZIFs with regulatable hydrophilic/hydrophobic surface. Journal of Colloid and Interface Science (JCR一区, IF 9.4), 2024, 667, 199-211.
[2] Geling Kuang, Zichen Wang, Xiuyan Luo, Zixin Geng, Jiandong Cui*, Muhammad Bilal, Ziyuan Wang*, Shiru Jia. Immobilization of lipase on hydrophobic MOF synthesized simultaneously with oleic acid and application in hydrolysis of natural oils for improving unsaturated fatty acid production. International Journal of Biological Macromolecules (JCR一区, IF 7.7), 2023, 242, 124807.
[3] Ziyuan Wang1, Yi Jiao1, Qingyuan Ding, Yanjie Song, Qingqing Ma, Huan Ren, Kun Lu, Shiru Jia, Jiandong Cui*. A bioinspired fluorescent probe based on metal–organic frameworks to selectively enrich and detect amyloid-β peptide. Chemical Engineering Journal (JCR一区, IF 16.7), 2023, 470, 144124.
[4] Lei Zhang, Ziyuan Wang*, Yi Jiao, Zichen Wang, Xiuming Tang, Zhanxin Du, Zeyang Zhang, Shihai Lu, Changsheng Qiao, Jiandong Cui*. Biodegradable packaging films with ε-polylysine/ZIF-L composites. LWT-Food Science and Technology (JCR一区, IF 6.056), 2022, 166, 113776.
[5] Yang Liu, Ziyuan Wang*, Yuxiao Feng; Yi Jiao, Le Zhong, Geling Kuang, Yingjie Du, Muhammad Bilal, Shiru Jia, Jiandong Cui*. Self assembled isoorotic acid‑zinc phosphate hybrid nanoflowers with superior antibacterial activity. Sustainable Materials and Technologies (JCR二区, IF 10.681), 2022, 32, e00432.
[6] Wang Ziyuan, Fengzhu Guo, Tianyu Dong, Zhilei Tan, Mohamed Abdelraof, Zichen Wang, Jiandong Cui*, and Shiru Jia*. Metabolomic analysis of biosynthesis mechanism of epsilon-Polylysine produced by Streptomyces diastatochromogenes, Frontiers in Bioengineering and Biotechnology (JCR二区, IF 4.383), 2021, 9, 698022.
[7] Zhong, Le, Yuxiao Feng, Hongtong Hu, Jiabao Xu, Ziyuan Wang*, Yingjie Du, Jiandong Cui*, and Shiru Jia. Enhanced enzymatic performance of immobilized lipase on metal organic frameworks with superhydrophobic coating for biodiesel production, Journal of Colloid and Interface Science (JCR二区, IF 7.489), 2021, 602, 426-436.
[8] Yingjie Du*, Xiaotong Jia, Le Zhong, Yi Jiao, Zhijin Zhang, Ziyuan Wang, Yuxiao Feng, Muhammad Bilal, Jiandong Cui*, Shiru Jia. Metal-organic frameworks with different dimensionalities: An ideal host platform for enzyme@MOF composites. Coordination Chemistry Reviews (JCR一区, IF 20.6), 2022, 454, 214327.
[9] Sizhu Ren, Ziyuan Wang, Muhammad Bilal, Yuxiao Feng, Yunhong Jiang*, Shiru Jia, Jiandong Cui*. Co-immobilization multienzyme nanoreactor with co-factor regeneration for conversion of CO2, International Journal of Biological Macromolecules (JCR一区, IF 5.162), 2020,155,110-118.
[10] Hongjie Bian, Gaoyang Wang, Menfei Cao, Ziyuan Wang, Jiandong Cui*. Improved biodegradation of poly(Vinyl alcohol) by hybrid nanoflowers of degrading enzymes from Bacillus niacin, Korean Journal of Chemical Engineering (JCR二区, IF 2.69), 2020, 37(6), 1020-1028.
[11] Huan Wen, Lei Zhang, Yingjie Du, Ziyuan Wang, Hongjie Bian, Shiru Jia, Jiandong Cui*. Bimetal based inorganic-carbonic anhydrase hybrid hydrogel membrane for CO2 sequestration, Journal of CO2 Utilization (JCR一区, IF 5.993), 2020, 39,101171.
[12] Le Zhong, Yuxiao Feng, Gaoyang Wang, ZiyuanWang, Muhammad Bilal, Hexin Lv*, Shiru Jia, Jiandong Cui*. Production and use of immobilized lipases in bioenergy: a review from the waste to biodiesel production, International Journal of Biological Macromolecules (JCR一区, IF 5.162), 2020, 152, 207-222.
[13] Baoting Sun, Zicheng Wang, Xiaoyi Wang, Mengxia Qiu, Zhijin Zhang, Ziyuan Wang, Shiru Jia, Jiandong Cui*. Paper-based biosensor based on phenylalnine ammonia lyase hybrid nanoflowers for urinary phenylalanine measurement, International Journal of Biological Macromolecules (JCR一区, IF 5.162), 2021, 166, 601-610.
[14] Ziyuan Wang, Xiaoyan Dong, Yan Sun*. Mixed carboxyl and hydrophobic dendrimer surface inhibits amyloid-beta fibrillation: New insight from the generation number effect, Langmuir (JCR二区, IF 3.683), 2019, 35, 14681-14687.
[15] Ziyuan Wang, Xiaoyan Dong, Yan Sun*. Hydrophobic modification of carboxyl-terminated polyamidoamine dendrimer surface creates a potent inhibitor of amyloid-beta fibrillation, Langmuir (JCR二区, IF 3.683), 2018, 34, 14419-14427.
[16] Ziyuan Wang, Shipeng Tao, Xiaoyan Dong, Yan Sun*. para-Sulfonatocalix[n]arenes inhibit amyloid beta-peptide fibrillation and reduce amyloid cytotoxicity, Chemistry-an Asian Journal (JCR二区, IF 4.056), 2017, 12, 341-346.
[17] Na Liu, Ziyuan Wang, Xiaoguang Liu, Linling Yu, Yan Sun*. Characterization of novel mixed-mode protein adsorbents fabricated from benzoyl-modified polyethyleneimine-grafted sepharose, Journal of Chromatography A (JCR二区, IF 4.049), 2014, 1372, 157-165.
[18] 焦晓波, 王子辰, 户红通, 李锦红, 王晓艺, 王梓源, 贾士儒, 孟国庆, 崔建东*. 芝麻渣中芝麻蛋白提取方法的比较研究, 生物技术通报, 2020, 34(4), 273-281.
[19] 王梓源, 李欣颖, 吕俊阁, 付萍, 孙雪文, 李雪晶, 谭之磊, 贾士儒*. ε-聚赖氨酸对大肠杆菌的抑菌机制, 食品与发酵工业, 2020, 46 (21), 34-41.
发明专利：
[1] 孙彦, 王梓源, 余林玲, 董晓燕. 疏水基团修饰的羧基端聚酰胺胺树状分子和制备方法及其抑制β淀粉样蛋白聚集的应用, 2021-01-22, 中国, 授权, ZL201811245728.5.
[2] 王梓源, 焦祎, 柴慈曼, 冯玉晓, 崔建东, 贾士儒. 一种基于双有机配体锌基金属有机框架材料的β-淀粉样肽荧光传感器及其制备方法和应用, 2023-04-24, 中国, 实质审查, 2023104492945.
联系方式
办公地点：天津经济技术开发区第十三大街29号永利集团3044浏览器
邮政编码：300457
办公电话：022-60602298
传 真：022-60602298
Email：ziyuan@tust.edu.cn
